Tau-316 Protein Recombinant
Catalog #
90327
$270
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Description
Human Tau-316, GenBank Accession No. P10636-3, full length, expressed in an E. coli expression system. MW = 39 kDa.
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Synonyms
Tau
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Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
MW
39 kDa
Amino Acids
full length
Genbank #
P10636-3
Background
Tau-316 encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. Tau-316 transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type (1). Tau-316 gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy (2).
References
1. Brown, J.et.al: Familial dementia with swollen achromatic neurons and corticobasal inclusion bodies: a clinical and pathological study. J. Neurol. Sci. 135: 21-30, 1996.
2. Alonso, A. D. C. et.al: Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nature Med. 2: 783-787, 1996.
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