Streptozocin (U-9889)

Catalog #

27656-1

$130 *

Size: 100 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.

●

Synonyms

Streptozotocin; U-9889; STZ; 1-methyl-1-nitroso-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

●

Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Formula

C₈H₁₅N₃O₇

265.2 Da

Solubility

Soluble in water (50 mg/ml), ethanol (3 mg/ml), and DMSO (50 mg/ml). Solutions are not stable; release of NO gas occurs spontaneously at room temperature. Prepare solutions immediately before use.

CAS Registry #

18883-66-4

Background

Streptozocin, also known as streptozotocin and U-9889, is a small molecule, N-nitroso-containing antibiotic and a potent DNA methylating agent. Streptozocin acts as a nitric oxide (NO) donor and vasorelaxant. In rat cell studies, this compound presented significant methylation of the liver, kidney, and pancreatic cells and selectivity for these cells against the more general methylating activity of the aglycone analog N-methyl-N-nitrosourea . Streptozocin shows particular activity in the pancreas, and has been used both to induce diabetes in mammals and to treat human pancreatic cancers.

References

1. Bennett, R A., et al., 1981. Cancer research. 41(7): 2786-90.
2. Brentjens, R., et al., 2001. The Surgical Clinics of North America. 81(3): 527-42.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Streptozocin (U-9889)

PRODUCTS

SERVICES

RESOURCES

COMPANY