Skd3 (E455Q), MBP-Tag Recombinant

Catalog #

101772

$320 *

Size: 100 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Recombinant human Skd3 (also known as ClpB, caseinolytic peptidase B protein homolog), encompassing amino acids 92-707(end). This construct contains an MBP (maltose binding protein) tag followed by a TEV protease site, and an E455Q mutation. This protein was affinity purified.

●

Synonyms

CLPB, HSP78, SKD3, Suppressor of potassium transport defect 3, Caseinolytic peptidase B protein homolog

●

Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Construct

SKD3 (E455Q) (MBP-TEV-92-707(end))

Mutation

E455Q

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution.

Formulation

50 mM Tris, pH 8.0, 300 mM KCl, 10% glycerol, 5 mM ATP, 10 mM MgCl₂, 3 mM DTT, and 10 mM Maltose

111 kDa

Amino Acids

92-707(end)

Genbank #

NM_030813.6

UniProt #

Q9H078

Tag(s)

N-terminal MBP-Tag

Background

Skd3 is a mitochondrial AAA ATPase protein that acts as a chaperone. It uses ATP hydrolysis to chaperone protein unfolding and disassembly, and to reverse protein aggregation. Sdk3 also plays a role in apoptosis by solubilizing HAX1 (HCLS-associated protein X-1). Mutations lead to metabolic disorders characterized by neutropenia, 3-methylglutaconic aciduria and developmental delays. Interestingly, Skd3 has been linked to Venetoclax resistance in the treatment of acute myeloid leukemia (AML), revealing its importance in AML therapy.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

●

Datasheets/Protocols

101772 Lot 230420

Datasheets provide example lot-specific information. Contact us to request information on currently available lots.

● General Protocols

● FAQs

● Contact Technical Service

Skd3 (E455Q), MBP-Tag Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY