Tph1/2 Screening Services

Tryptophan hydroxylase 1 and 2 (Tph1/2) enzymes catalyze the monooxygentation of tryptophan to 5-hydroxytryptophan (5-HTP). Following monooxygentation, 5-HTP is decarboxylated and converted to serotonin. Through tryptophan depletion, TPH1 and TPH2 can inhibit immune system function in a manner similar to IDO1,2 and TDO. As tumor cells overexpress enzymes like Tph1/2, immune cells are deprived of essential amino acids and have impaired abilities to fight cancer.  

More specifically, TPH1 and TPH2 enzymes have been linked to many types of immune system regulation. In mice, Tph1 has been implicated in regulating tumor growth, the tolerance of transplanted tissues, inflammation, and autoimmunity. Additionally, excessive Tph1/2 activity results in depleted tryptophan and this causes reduced mTOR signaling. Tph1/2 can have a significant impact on the immune system and due to its diverse effects, it is a key drug target in immunotherapy.

In addition to Tph related products, BPS also offers Tph1/2 screening services. Using BPS’s screening services, we can help accelerate your research and drug discovery programs. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy to:

  • Screen for inhibitors/targets using our TPH1/2  assay
  • Select from IC50 determination and single point concentrations
  • Receive data within days of compound submission
  • Perform follow-up studies using the same soluble receptors manufactured in-house
  • Get questions anwered or project guidance in a time-efficient manner

Contact BPS today to find out more about how we can assist you in your TPH1/2 related research

Not quite what you’re looking for? 
BPS offers Cell-Based Immunotherapy Assay Screening Services for certain Immunotherapy targets. In addition, our Custom Assay Development Services allow for flexibility to meet your specific research needs