Cell Signaling Pathway Screening & Profiling

In order to determine effectors of cell signaling pathways in the context of intact functioning cells, cell-based reporter assays are an ideal option. Using luciferase reporters downstream of a pathway-specific promoter response element, signaling activity can be conveniently measured by the output of luciferase activity. The system can be applied across a wide variety of cell types and signaling pathways and allows for high throughput screening of large libraries of compounds for inhibitory or activating function.

We offer rapid and dependable screening and profiling services for cell signaling pathway effectors. Our team of experts, using our broad portfolio of in-house developed cell-based assay kits, can provide:

  • Screening for active compounds (small molecules, peptides, or antibodies)
  • Determination of IC50 or EC50
  • Project guidance and questions answered in a timely manner
  • Delivery of detailed results promptly and on time
Cell Signaling Pathway Screening and Profiling Services

In order to determine effectors of cell signaling pathways in the context of intact functioning cells, cell-based reporter assays are an ideal option. Using luciferase reporters downstream of a pathway-specific promoter response element, signaling activity can be conveniently measured by the output of luciferase activity. The system can be applied across a wide variety of cell types and signaling pathways and allows for high throughput screening of large libraries of compounds for inhibitory or activating function.

We offer rapid and dependable screening and profiling services for cell signaling pathway effectors. Our team of experts, using our broad portfolio of in-house developed cell-based assay kits, can provide:

  • Screening for active compounds (small molecules, peptides, or antibodies)
  • Determination of IC50 or EC50
  • Project guidance and questions answered in a timely manner
  • Delivery of detailed results promptly and on time
Cell Signaling Pathway Screening and Profiling Services

If your desired cell-based assay is not available, we may be able to develop a custom product for you.

Learn more about the process and deliverables.

Diabetes & Obesity

  • GLP-1R, GIPR, and GCGR luciferase reporter cell lines provide convenient readouts for agonist function.
  • TRβ luciferase reporter cells enable specific receptor activation for MASH.

Cytokine Stimulation

  • Cytokines are critical for immune activation or suppression. Our cytokine responsive cell lines provide excellent tools for drug discovery, targeting IFNγ, IL-2, IL-6, IL-15, IL-17, TGFβ, TL1A, and more.

Phosphodiesterase/cAMP

  • We provide multiple cell lines for phosphodiesterase inhibitor screening using the CREB/CRE promoter system.

Neuroscience

  • Highly sensitive reporter cells expressing CGRPR, NCAM1, Notch1, TrkA and more facilitate neuroscience discovery.

Available Service Assays

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Ligand/Activator
Engineered Receptor
Transcription Factor/Promoter
Reporter
Parental Cell Line
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Note: Not all targets will have a commercially available reference control. Please inquire with our team if you need to furnish your own controls for specific targets.