RON, GST-tag Recombinant

Catalog #

40292

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human RON (a.a. 983-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

MST1R, PTK8, CDw136

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

71 kDa

Amino Acids

983–end

Genbank #

NM_002447

UniProt #

Q04912

Tag(s)

N-terminal GST-tag

Background

RON is a macrophage stimulating 1 receptor c-met-related tyrosine kinase (1). RON receptor tyrosine kinase interacts with HYAL2 receptor protein, rendering it functionally inactive. HYAL2 is a candidate tumor-suppressor glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. It was shown that RON liberated from the association with HYAL2 becomes functionally active and activates the Akt and mitogen-activated protein kinase pathways (2).

References

1. Wang, M.H. et al: Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science, 1994; 266 (5182): 117-9.
2. Li, B,Q, et al: "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. Biochem. Biophys. Res. Commun.1995; 216 (1): 110-8.

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RON, GST-tag Recombinant

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