RbBP5, His-tag Recombinant

Catalog #

71202

$450 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 – 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.

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Synonyms

Rbbp5, retinoblastoma binding protein 5, Set1c WD40 Repeat Protein, SWD1, RBQ3

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Product Data Gallery

10% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥65%

Format

Aqueous buffer solution

Formulation

20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 µM ZnCl₂

60 kDa

Amino Acids

2–538 (end)

Genbank #

NM_005057

UniProt #

Q15291

Tag(s)

N-terminal His-tag

Background

RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.

References

1. Cao, F., et al., PLoS One. 2012 Nov 23; 5(11): e14102.
2. Odho, Z., et al., J Biol Chem. 2010 Oct 22; 285(43): 32967-76.

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Datasheets/Protocols

71202_Lot120206-G.pdf

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RbBP5, His-tag Recombinant

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