Human RANTES (CCL5) Recombinant

Catalog #

90232-A

$130 *

Size: 5 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Synonyms

CCL5, RANTES, Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted, Eosinophil Chemotactic Cytokine, Small-Inducible Cytokine A5, T-Cell Specific Protein P28

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered PBS solution.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–91

Biological Activity

Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.

Genbank #

P13501

UniProt #

P13501

Background

RANTES belongs to the family of chemotactic cytokines known as Chemokines. RANTES is expressed by an early response gene. The synthesis of RANTES is induced by TNF-alpha and IL-1alpha. RANTES is chemotactic for T-cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. RANTES also activates eosinophils to release eosinophilic cationic protein. It changes the density of eosinophils and makes them hypodense, which is thought to represent a state of generalized cell activation and is associated most often with diseases such as asthma and allergic rhinitis. RANTES also is a potent activator of oxidative metabolism specific for eosinophils. RANTES increases the adherence of monocytes to endothelial cells. It selectively supports the migration of monocytes and T-lymphocytes expressing the cell surface markers CD4 and UCHL1. These cells are thought to be pre-stimulated T-helper cells with memory T-cell functions. RANTES activates human basophils from some select basophil donors and causes the release of histamines.

References

1. Lv, D., et al. Cell Mol Immunol. 2013 Jul,10(4):303-10.
2. Suffee N, et al.
2. Biochem Soc Trans. 2011 Dec,39(6):1649-53.
3. Katsounas A, et al. Int Rev Immunol. 2011 Oct-Dec,30(5-6):366-78.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Human RANTES (CCL5) Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY