Brefeldin A

Catalog #

27042

$165 *

Size: 10 mg

Qty

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Description

Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus and induces apoptosis in human tumor cells via caspase activation. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

White to off-white solid.

Formula

C₁₆H₂₄O₄

280.4 Da

Solubility

Soluble in DMSO at 100 mg/ml; soluble in 100% ethanol at 25 mg/ml with slight warming, methanol, acetone or ethyl acetate (1 mg/ml). Very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM

CAS Registry #

20350-15-6

References

1. Misumi, Y., et al. J. Biol. Chem. 261: 11398-11403 (1986).
2. Guo, H., et al. Exp. Cell Res. 245: 57-68 (1998).
3. Linardic, C. M., et al. Cell Growth Differ. 7: 765-774 (1996).

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Brefeldin A

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