NAD+, Biotin-Labeled
Biotinylated NAD+ (6-biotin-17-nicotinamide-adenine-dinucleotide, 6-biotin-17-NAD).
This product has been cited 12 times.
C45H67N12O18P2S
This protein is enzymatically biotinylated.
PAR homeostasis is regulated by the family of PAR polymerases (PARPs) and PARG (Poly (ADP-ribose) glycohydrolase) in response to cellular stress conditions. ADP ribosylation, which is the addition of an ADP-ribose to a protein, is a reversible post-translational modification of proteins mostly involved in the DNA Damage Response (DDR) pathway. Poly-ADP-ribosylation (termed PARylation) is the addition of linear or branched chains of ADP-ribose. PARP and PARG activity are linked to cellular responses in inflammation, ischemia, stroke, and cancer. PARP inhibitors have been used in cancer treatment with success, leading to synthetic lethality when homologous recombination repair (HRR) is already defective. Further studies of PARP will elucidate how the levels of PARylated proteins contribute to disease and can be modulated to provide therapeutic benefit.
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2. Zhang, J. (1997). Meth. Enzymol. 280: 255-65.
3. Till, S., and Ladurner, A.G. (2009). Front Biosci. 14:3246-3258.
4. Ying, W. (2007). Front Biosci. 12:1863-88.
5. Ying, W. (2008). Antioxidants & Redox Signaling. 10(2):179-206.
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