PHIP (BD1), GST-tag Recombinant

Catalog #

31142

$305 *

Size: 100 µg

Qty

Bulk/Custom

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Description

Human bromodomain pleckstrin homology domain interacting protein (PHIP), also known as IRS-1 PH Domain-Binding Protein, WDR11, and BRWD2, GenBank Accession No. NM_017934, a.a. 1146 - 1287 corresponding to bromodomain 1 , with N-terminal GST-tag, MW = 43 kDa, expressed in an E. coli cell expression system.

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Synonyms

bromodomain pleckstrin homology domain interacting protein, IRS-1 PH Domain-Binding Protein, WDR11, BRWD2

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥71%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.

43 kDa

Amino Acids

1146 – 1287

Genbank #

NM_017934

UniProt #

Q8WWQ0

Tag(s)

N-terminal GST-tag

Background

PHIP is a bromodomain-containing protein that binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1 ), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival. It stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation.

References

1. De Semir, D., et al., Proc. Natl. Acad. Sci. USA. 2012 May 1;109(18):7067-72.
2. Farhang-Fallah, J., et al., J. Biol. Chem. 2000 Dec 22;275(51):40492-7.

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Datasheets/Protocols

31142_Lot130724-G1.pdf

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