PASK, GST-tag Recombinant
Catalog #
40149
$410
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Description
Recombinant human PASK (a.a. 981-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
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Synonyms
STK37; PASKIN; KIAA0135; DKFZp434O051; DKFZp686P2031
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥75%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
66 kDa
Amino Acids
981–end
Genbank #
NM_015148
UniProt #
Q96RG2
Background
PASK or PAS domain containing serine/threonine kinase regulates the function of many intracellular signaling pathways involved in stress. PASK is involved in sensing environmental changes in light intensity, oxygen concentration and redox potential. Through interaction with IRS-1, PASK has been proposed as a counter-regulatory mechanism in insulin and cytokine signaling (1). PASK can phosphorylate and inactivate glycogen synthase in vitro. Efficient phosphorylation requires residues 444 to 955 of PASK between the PAS and catalytic kinase domain and this interaction is inhibited by the PAS domain.
References
Nagase, T. et al: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1996; 2 (4): 167–74, 199–210.
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