Mouse PAK3, GST-tag Recombinant

Catalog #

40147

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant mouse PAK3, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

Stk4, mPAK-3, Pak65beta, Pak65alpha

Product Info

Storage and Usage

Citations

Species

Mouse

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

89 kDa

Amino Acids

full length

Genbank #

NM_008778

Tag(s)

N-terminal GST-tag

Background

PAK3 is a member of the family of serine/threonine p21-activating kinases that serve as targets for the small GTP binding proteins Cdc42 and RAC (1). The PAK family of proteins have been implicated in a wide range of biological activities and are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK3 seems to be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in PAK3 gene has been linked to nonsyndromic X-linked mental retardation (2).

References

1. Manser, E. et al: Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270: 25070-25078, 1995.
2. Bienvenu, T. et al: Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation. Am. J. Med. Genet. 93: 294-298, 2000.

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Mouse PAK3, GST-tag Recombinant

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