NEU2, His-Tag Recombinant

Catalog #

101722

$305 *

Size: 25 µg

Qty

Bulk/Custom

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Description

Recombinant NEU2 (Neuroaminidase 2 or sialidase-2), full length, encompassing amino acids 2-380(end). This construct contains an N-terminal His-Tag (6xHis). This recombinant protein was affinity purified.

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Synonyms

Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

NEU2 inhibition curve using a fluorogenic assay (#82139). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations

Species

Human

Construct

NEU2 (His-2-380(end))

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution.

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

43 kDa

Amino Acids

2-380(end)

Genbank #

NM_005383.2

UniProt #

Q9Y3R4

Tag(s)

N-terminal His-Tag

Background

NEU2, also known as neuroaminidase 2 or sialidase-2, is a glycohydrolytic enzyme involved in the removal of sialic acid from either proteins or lipids. This enzyme is present at low levels in most tissues but plays a crucial role in carcinogenesis. Cytosolic NEU2 regulates the PI3K-Akt/mTOR pathway and is thus involved in apoptosis, drug resistance, and cancer cell migration.

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Datasheets/Protocols

101722 Lot 230411-2

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