MRCKβ, GST-tag Recombinant

Catalog #

40130

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human Myotonic Dystrophy Kinase-Related cdc42-binding kinase beta (MRCKβ), a.a. 1-473, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

CDC42BPB, KIAA1124, MRCKbeta

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

73 kDa

Amino Acids

1–473

Genbank #

NM_006035

UniProt #

Q9Y5S2

Tag(s)

N-terminal GST-tag

Background

Myotonic Dystrophy Kinase-Related cdc42-binding kinase beta (MRCKβ) belongs to the DMPK subfamily (1). The myotonic dystrophy kinase-related kinases and myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) are effectors of RhoA and Cdc42, respectively, where they are involved in actin cytoskeletal reorganization and neurite outgrowth (2). Effects of the repeat expansion on the DMPK gene may be responsible for muscle and heart features of Myotonic Dystrophy.

References

1. Lam. L T. et al: Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. Hum. Mol. Genet. 2000; 9(14): 2167-73.
2. Tan, I. et al: Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. J. Biol Chem. 2001; 276(24):21209-16.

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MRCKβ, GST-tag Recombinant

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