MRCKα, GST-tag Recombinant
Catalog #
40129
$410
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Description
Recombinant human Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase alpha (MRCKα), a.a. 1-473, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
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Synonyms
CDC42BPA, MRCK, PK428, FLJ23347, KIAA0451, DKFZp686L1738, DKFZp686P1738, MRCKalpha
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Product Data Gallery
10% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥70%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
73 kDa
Amino Acids
1–473
Genbank #
NM_003607
UniProt #
Q5VT25
Background
Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase α (MRCKα) is a Cdc42/Rac/Rho interactive/binding serine/threonine kinase with multiple functional domains (1). MRCK are effectors of RhoA and Cdc42, respectively, for actin reorganization. MRCKα is a critical regulator of signal transduction pathways in eukaryotic cells that are known principally for their role in regulating the cytoskeleton, and they do so by recruiting a variety of downstream effector proteins (2).
References
1. Ivan, T. et al: Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase α reveals multiple alternative splicing and functional diversity. Gene; 2003; 304:107-115.
2. Ivan, T. et al: Phosphorylation of a Novel Myosin Binding Subunit of Protein Phosphatase 1 Reveals a Conserved Mechanism in the Regulation of Actin Cytoskeleton. J. Biol. Chem., 2001: 276 (24): 21209-21216.
2. Ivan, T. et al: Phosphorylation of a Novel Myosin Binding Subunit of Protein Phosphatase 1 Reveals a Conserved Mechanism in the Regulation of Actin Cytoskeleton. J. Biol. Chem., 2001: 276 (24): 21209-21216.
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