Geldanamycin

Catalog #

27008

$120 *

Size: 10 µl

Qty

Bulk/Custom

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Description

Geldanamycin is an antibiotic and a potent antitumor compound. It inhibits pp60src tyrosine kinase, and it also binds specifically to heat shock protein Hsp90 and its GP96 homologue. It is known to inhibit protein maturation.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC.

Format

Diluted in DMSO

Concentration

10 mM

Formula

C₂₉H₄₀N₂O₉

560.6 Da

Solubility

Soluble in anhydrous DMSO at 100 mg/ml. Poorly soluble in methanol. Ethanol and water are not recommended for stock solutions. The maximum water solubility is estimated to be ~ 20 – 50 µM.

Biological Activity

Geldanamycin strongly inhibited Hsp90 protein as shown through inhibited Plasmodium falciparum growth in human erythrocyte culture with an IC50 of 20 nM.

CAS Registry #

30562-34-6

References

1. Whitesell, L. and Cook, P. Mol. Endocr. 10: 705 – 712 (1996)
2. Rajinder, K., et al., Malaria Journal 2:30 (2003)

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Geldanamycin

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