Human Keratinocyte Growth Factor Recombinant
Catalog #
90205-A
$130
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Description
Recombinant human Keratinocyte Growth Factor is a disulfide-linked monomeric protein consisting of 164 amino acid residues. Optimized DNA sequence encoding Human Keratinocyte Growth Factor mature chain was expressed in E. coli. Native human KGF is generated by the proteolytic removal of the signal peptide and propeptide. KGF migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
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Synonyms
Keratinocyte Growth Factor, KGF
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥96% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 1M NaCl, pH 8.0.
MW
19 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity
The ED50 was determined by the dose-dependent proliferation of BAF3 cells to be less than 10 ng/ml.
UniProt #
P21781
Background
KGF is a member of the family of fibroblast growth factors, it is secreted in large amounts by fibroblast-like stromal cells in epithelial tissues. The KGF receptor encodes a tyrosine kinase and is a member of the family of receptors binding aFGF and bFGF. Binding of KGF to its receptor is competed by aFGF and bFGF. Although KGF is a potent specific mitogen for many epithelial cells, it is not so for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells. KGF stimulates the proliferation of primary and secondary human keratinocytes to the same extent as EGF.
References
1. Anticancer Res, Aug 2009, 29: 3417 - 3420.
2. Anticancer Res, Aug 2009, 29: 3195 - 3205.
3. Am. J. Respir. Cell Mol. Biol., Feb 2008, 38: 239 - 246.
2. Anticancer Res, Aug 2009, 29: 3195 - 3205.
3. Am. J. Respir. Cell Mol. Biol., Feb 2008, 38: 239 - 246.
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