Human ITAC(CXCL11) Recombinant

Catalog #

90204-A

$130 *

Size: 5 µg

Qty

Bulk/Custom

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Description

Recombinant human CXCL11 (ITAC) is a disulfide-linked monomeric protein consisting of 74 amino acid residues and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human ITAC (CXCL11) mature chain was expressed in E. coli.

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Synonyms

ITAC, CXCL11, IFN-inducible T- cell -chemoattractant, I-TAC

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 100 mM NaCl, pH 7.5.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

22–94

Biological Activity

Determined by its ability to chemoattract human T cells using a concentration range of 2.0-10.0 ng/ml.

Genbank #

O14625

UniProt #

O14625

Background

The CXC chemokine ligand 11 (CXCL11) or IFN-inducible T-cell-chemoattractant (I-TAC) belongs to the CXC chemokine family characterized by the presence of 1 amino acid in between the 2 NH₂-terminal cysteines. CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). Simultaneous stimulation of fibroblasts or endothelial cells with IFN-gamma and interleukin-1b or the TLR3 ligand double-stranded RNA resulted in a synergistic increase of CXCL11 production. CXCL11 attracts activated T-helper 1 (Th1) lymphocytes and natural killer (NK) cells. Like CXCL9 and CXCL10, CXCL11 signals through CXC chemokine receptor 3 (CXCR3).

References

1. J. Biol. Chem., Jul 2008, 283: 19389 - 19399.
2. Blood, Oct 2008, 112: 2648 - 2656.

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Human ITAC(CXCL11) Recombinant

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