IKKβ Kinase Assay Kit
The IKKβ Kinase Assay Kit is designed to measure the kinase activity of IKKβ for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
- Kinase-Glo MAX (Promega #V6071)
- Microplate reader capable of reading luminescence
- Adjustable micropipettor and sterile tips
- 30°C incubator
| Catalog # | Name | Amount | Storage |
| 40304 | IKKβ, GST-Tag Recombinant* | 20 µg | -80°C |
| 79334 | Kinase assay buffer 1 (5x) | 1.5 ml | -20°C |
| 79686 | ATP (500 µM) | 100 µl | -20°C |
| IKKtide (1 mg/ml) | 1 ml | -20°C | |
| 79696 | White 96-well plate | 1 | Room Temp |
*The concentration of the protein is lot-specific and will be indicated on the tube
The IKKβ (inhibitor of nuclear factor kappa B kinase subunit beta) is a protein subunit encoded by the IKβKβ (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene which activates NF-κB (nuclear factor kappa-light chain enhancer of activated B cells) signaling. NF-κB is a family of transcription factors that regulate gene expression in a variety of tissue types. Mutations in IKKB result in defective NF-κB signaling leading to immunological disorders. Exploring novel mutations in IKKB may elucidate the causation of sporadic and unexplained diseases.
Cardinez, C., Miraghazadeh, et al., Journal of Experimental Medicine, 215(11), 2715–2724.
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