Human Growth Hormone 192AA Recombinant

Catalog #

90142-A

$130 *

Size: 100 µg

Qty

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Description

Recombinant human growth hormone is a disulfide-linked monomeric protein consisting of 192 a.a. and migrates as an approximately 22 kDa protein under reducing and non-reducing conditions. Optimized DNA sequence encoding human growth hormone mature chain was expressed in E. coli.

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Synonyms

growth hormone, GH1, Somatotropin

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered solution of 5 µM NaHCO₃, pH 10.

22 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

27–217

Biological Activity

Determined by a dose-dependent cell proliferation assay using the rat lymphoma, Nb2-11, to be in the range of 0.1 ng/ml.

Genbank #

P01241

UniProt #

P01241

Background

The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass, most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the cytokine receptor families. Growth hormone has been shown to be produced by T- cells, B-cells, and macrophages. In human lymphocytes, growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T- helper cells.

References

1. Pediatrics. Nov. 2010, 126(5): e1211-26.
2. Handbook Exp. Pharmacol. 2010, (195):187-200.
3. Horm Res. Nov. 2009, 72 Suppl 1: 60-4.

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Human Growth Hormone 192AA Recombinant

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