Mouse FER, GST-tag Recombinant

Catalog #

40419

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant mouse FER (a.a. 542-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

Fert, Fert2, AV082135, C330004K01Rik

Product Info

Storage and Usage

Citations

Species

Mouse

Host Species/Expression System

Sf9 insect cells

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

59 kDa

Amino Acids

542–end

Genbank #

NM_001037997

Tag(s)

N-terminal GST-tag

Background

FER is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. FER plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions (1). Genetic analysis using transgenic mouse models implicate FER in the regulation of inflammation and innate immunity. Fer-deficient mice displayed enhanced recruitment of leukocytes in response to local LPS challenge. FER is required for cell-cycle progression in malignant cells. Decreasing the level of FER using RNAi impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase (2).

References

1. Greer, P.: Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol. 2002 Apr;3(4):278-89.
2. Pasder, O. et al: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006 Jul 13;25(30):4194-206.

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Mouse FER, GST-tag Recombinant

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