Human Exodus-2 Recombinant
Catalog #
90132-A
$130
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Description
Recombinant Exodus-2 is a disulfide-linked homodimeric protein consisting of 112 amino acid residues, and migrates as an approximately 12 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Exodus-2 mature chain was expressed in E. coli.
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Synonyms
CCL21, SCYA21, Exodus-2
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered solution in 2.5% glycine, 0.5% sucrose, 0.01% Tween-80, 5 mMglutamic acid, pH 4.5.
MW
12 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
24–134
Biological Activity
Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.
Genbank #
O00585
UniProt #
O00585
Background
Exodus-2, which is a member of the family of CC- Chemokines, has a unique 36 (murine) or 37 (human) amino acid carboxyl-terminal extension not seen in other chemokines. Exodus-2 selectively stimulates the chemotaxis of adult T-lymphocytes and is expressed preferentially in lymph node tissue. Exodus-2 is critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T-cell trafficking through nodal tissue.
References
J. Exp. Med., Jan 2000, 191: 61.
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