Human ENA-78(CXCL5) Recombinant

Catalog #

90124-A

$130 *

Size: 5 µg

Qty

Bulk/Custom

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Description

Recombinant CXCL5 is a disulfide-linked monomeric protein consisting of 75 amino acid residues and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human ENA-78 (CXCL5) mature chain was expressed in E. coli.

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Synonyms

ENA-78, SCYB5, CXCL5, Chemokine (C-X-C Motif) Ligand 5, Epithelial-Derived Neutrophil Activating Protein 78

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered 20 mM phosphate buffer, 100 mM NaCl solution, pH 7.5.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Biological Activity

Determined by its ability to chemoattract human neutrophils using a concentration range of 2.0-40.0 ng/ml.

Genbank #

P42830

UniProt #

P42830

Background

Epithelial neutrophil- activating protein 78 (ENA-78) is a member of the CXC chemokines and acts as a potent chemoattractant and activator of neutrophil function. On stimulation in vitro, ENA-78 is highly expressed in many cell types. ENA-78 protein levels are strongly elevated in synovial fluid and blood of patients with rheumatoid arthritis. By in situ hybridization and immunofluorescence staining, ENA-78 has been recognized as a major CXC chemokine expressed in epithelial cells of the intestinal mucosa of patients with Crohn's disease, ulcerative colitis, and acute appendicitis.

References

1. J. Immunol., Mar 2011, 186: 3197 - 3205.
2. J. Immunol., Nov 2010, 185: 6214 - 6225.
3. J. Biol. Chem., Sep 2010, 285: 29750 - 29759.

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Human ENA-78(CXCL5) Recombinant

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