Doramapimod

Catalog #

27034

$160 *

Size: 25 mg

Qty

Bulk/Custom

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Description

Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL(T315I), with an IC50 of 2-3 µM.

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Synonyms

BIRB 796

Product Info

Storage and Usage

Citations

Purity

≥98%

Format

White to off-white solid.

Formula

C₃₁H₃₇N₅O₃

527.7 Da

Solubility

Soluble in DMSO at 50 mg/ml; soluble in ethanol at 30 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM

CAS Registry #

285983-48-4

References

1. Branger, J., et al. J. Immunol. 168: 4070-4077 (2002).
2. Carter, T.A., et al. Proc. Natl. Acad. Sci. USA 102: 11011-11016 (2005).

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