p38δ (p38delta), GST-tag Recombinant
Catalog #
40145
$410
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Description
Recombinant human P38δ also known as MAPK13 (mitogen-activated protein kinase 13), encompassing full length amino acids. This construct contains an N-terminal GST-tag. The recombinant protein was affinity purified and is kinase active.
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Synonyms
SAPK4; PRKM13; MAPK13, p38
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Specific Activity
Product Info
Storage and Usage
Citations
Species
Human
Construct
p38δ (GST-Full Length)
Host Species/Expression System
Sf9 insect cells
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
MW
71 kDa
Amino Acids
full length
Genbank #
NM_002754
UniProt #
O15264
Background
p38δ (SAPK4) is a member of the p38 MAPK family and is activated by chemical and environmental stresses as well as by proinflammatory cytokines. p38δ has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).
References
1. Goedert, M. et al: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16: 3563-3571, 1997.
2. Kumar, S. et al: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.
2. Kumar, S. et al: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.
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