DBeQ

Catalog #: 27703-1
Size: 10 mg
$155
MW: 340.4 Da
CAS Registry #: 177355-84-9
Formula: C22H20N4
Description:
DBeQ is cell permeable, potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks both ubiquitin dependent and endoplasmic reticulum-associated degradation pathways, protein clearance pathways, and activates caspases -3 and -7 inducing apoptosis.
Synonym(s):
JRF 12; DBeQ; N2,N4–Dibenzylquinazoline–2,4–diamine
Purity:
>98% by TLC.
Solubility:
Soluble in DMSO (25 mg/ml)
Format:
Yellow powder
Storage / Stability:

Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.

Application(s):
Useful for the study of the ubiquitin-dependent and endoplasmic reticulum-associated degradation pathway (p97 ATPase)
Reference(s):
1. Chou TF, et al. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. USA. 2011. Mar 22; 108:4834-9.
Warning(s):
Protect from moisture.
Scientific Category:
Ubiquitin Enzymes
Product Type:
Inhibitors/Activators
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