CLK2, GST-tag Recombinant

Catalog #

40197

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human CLK2 (a.a. 137-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

hCLK2, MGC61500

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

68 kDa

Amino Acids

137–end

Genbank #

NM_003993

UniProt #

P49760

Tag(s)

N-terminal GST-tag

Background

CDC-like kinase 2 (CLK2) a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases) was shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems (1). Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the clk-2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length (2).

References

1. Jiang, N. et al: Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J. Biol. Chem. 2003;278(24):21678-84.
2. Nayler, O. et al: The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. J. Biol. Chem. 1998;273(51):34341-8.

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CLK2, GST-tag Recombinant

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