Bioluminescent Cells for Cell Line-Derived Xenograft (CDX) Models

Cell line-derived xenograft (CDX) models are important in vivo models that serve to determine anti-tumor efficacy, pharmacokinetics/pharmacodynamics, toxicity, and other characteristics of drug candidates. They can be used effectively across a range of therapeutic modalities, including small molecules, antibodies, and CAR-T, among others. BPS Bioscience has specifically engineered human-derived cell lines constitutively expressing firefly luciferase or eGFP for convenient bioluminescence or fluorescence imaging of CDX models.

A typical workflow for CDX model studies

CDX models can be done in mouse or rat systems either as subcutaneous, disseminated, or orthotopic (localized) models. With BPS Bioscience cell lines, you can quickly apply them to your desired CDX model for convenient readouts. 

Why choose BPS Bioscience cell lines for CDX?

• Firefly luciferase is an excellent option for bioluminescence imaging with little background.
• Cell lines are derived from a single clone with uniform expression of luciferase, delivering consistent readouts.
• Each cell line includes recommendations for our optimized thaw and growth media for cell culture.
• Well established, well characterized human cell lines, including Raji, MM.1S, MC38, K562, Jurkat, SKOV-3 and more.
• Verified mycoplasma-free and low endotoxin.
• Convenient access to technical product support with rapid turnaround times.