CD39 & CD73: Adenosine Signaling
Therapeutic antibodies targeting checkpoint receptors such as PD-1 and CTLA4 are giving new hope to cancer patients. However, not all patients respond to treatment and the search for effective co-therapies is driving substantial research. Two critical enzymes of this pathway, CD39 and CD73 , are promising targets for increasing the effectiveness of checkpoint-based immunotherapies. 1
The hydrolysis of extracellular ATP to AMP is...
CD73 Screening Services
CD73, or cluster of differentiation 73, is an enzyme which hydrolyzes AMP to adenosine. Increased concentrations of adenosine in the microenvironment has an immunosuppressive effect and promotes tumor cell growth.
Adenosine can enhance tumor growth via two mechanisms – 1) binding of adenosine to A2A and A2B receptors expressed on tumor cells directly promotes tumor cell proliferation and 2) binding of adenosine to A2A and A2B receptors on immune cells su...
A2aR & Immunotherapy
The great need for treatments and the promise of cures are driving the search for second-generation immunotherapies beyond therapeutic antibodies targeting PD-1 and CTLA4 pathways. Immunotherapies are not limited to just therapeutic antibodies . Small-molecule inhibitors are showing great promise in clinical trials. For example, inhibitors targeting the enzymatic pathways, such as tryptophan catabolism are in late-phase clinical develop...
Immunotherapy Biochemical Screening Services
Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...
CD39 Screening Services
Cluster of differentiation 39, (CD39), is a cell surface enzyme that is highly expressed on regulatory T cells and plays an important role in modulating immune cell function. CD39 hydrolyzes ATP to ADP which can subsequently be hydrolyzed by CD73 to adenosine.. Adenosine can enhance tumor growth via two mechanisms – 1) binding of adenosine to A2A and A2B receptors expressed on tumor cells directly promotes tumor cell proliferation and 2) binding ...
COX1 & COX2 Screening Services
Prostanoids are signaling molecules which mediate inflammation and vasoconstriction. These signaling molecules are formed through the action of cyclooxygenase (COX) enzymes. Two COX isoforms exist, COX1 and COX2. COX1 helps to produce mucus lining for the stomach and is also expressed in a variety of other tissue types. Meanwhile, COX2 expression is generally restricted to inflamed cells and works to upregulate prostanoid levels.
COX enzyme...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
