Brefeldin A

Catalog #: 27042
Size: 10 mg
$160
MW: 280.4 Da
CAS Registry #: 20350-15-6
Formula: C16H24O4
Description:
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus and induces apoptosis in human tumor cells via caspase activation. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.
Purity:

≥99%

Solubility:
Soluble in DMSO at 100 mg/ml; soluble in 100% ethanol at 25 mg/ml with slight warming, methanol, acetone or ethyl acetate (1 mg/ml). Very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 ┬ÁM
Format:
White to off-white solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Misumi, Y., et al. J. Biol. Chem. 261: 11398-11403 (1986).
2. Guo, H., et al. Exp. Cell Res. 245: 57-68 (1998).
3. Linardic, C. M., et al. Cell Growth Differ. 7: 765-774 (1996).
Scientific Category:
Protease
Product Type:
Activator
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