Brefeldin A

Catalog #: 27042
Size: 10 mg
MW: 280.4 Da
CAS Registry #: 20350-15-6
Formula: C16H24O4
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus and induces apoptosis in human tumor cells via caspase activation. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.


Soluble in DMSO at 100 mg/ml; soluble in 100% ethanol at 25 mg/ml with slight warming, methanol, acetone or ethyl acetate (1 mg/ml). Very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 ┬ÁM
White to off-white solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
1. Misumi, Y., et al. J. Biol. Chem. 261: 11398-11403 (1986).
2. Guo, H., et al. Exp. Cell Res. 245: 57-68 (1998).
3. Linardic, C. M., et al. Cell Growth Differ. 7: 765-774 (1996).
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