BIBR 1532

Catalog #: 27740-1
Size: 25 mg
MW: 331.4 Da
CAS Registry #: 321674-73-1
Formula: C21H17NO3
Target: Telomerase
It has been reported that BIBR 1532 inhibited the reverse transcriptase of telomerase, hTERT, and shortened the length of the telomerase to suppress human cancer cell proliferation. In pre-B acute lymphoblastic leukemia cells, BIBR1532 suppressed c-Myc and hTERT expression in a concentration-dependent manner to inhibit telomerase activity, and high doses of BIBR1532 could induce apoptosis by elevating p73, Bax/Bcl-2 and caspase-3 activation. In NB4 leukemic cells, combined treatments with BIBR 1532 and arsenic trioxide suppressed cell proliferative capacity and inhibited telomerase activity probably via transcriptional suppression of c-Myc and hTERT.
BIBR 1532 is a novel, specific telomerase inhibitor with IC50 = 93 nM.
2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid
Soluble in DMSO
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

1. Damm, K., et al. EMBO J. 2001, 20, 6958?6968.
2. Bashash D., et al. Leuk Lymphoma. 2013 Mar;54[4]:561-8.
3. Bashash D., et al. Anticancer Agents Med Chem. 2013 Sep;13(7):1115-25.
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