BIBR 1532

Catalog #

27740-1

$230 *

Size: 25 mg

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Description

BIBR 1532 is a novel, specific telomerase inhibitor with IC50 = 93 nM.

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Synonyms

2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid

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Product Info

Storage and Usage

Citations

Target(s)

Telomerase

Formula

C₂₁H₁₇NO₃

331.4 Da

Solubility

Soluble in DMSO

CAS Registry #

321674-73-1

Background

It has been reported that BIBR 1532 inhibited the reverse transcriptase of telomerase, hTERT, and shortened the length of the telomerase to suppress human cancer cell proliferation. In pre-B acute lymphoblastic leukemia cells, BIBR1532 suppressed c-Myc and hTERT expression in a concentration-dependent manner to inhibit telomerase activity, and high doses of BIBR1532 could induce apoptosis by elevating p73, Bax/Bcl-2 and caspase-3 activation. In NB4 leukemic cells, combined treatments with BIBR 1532 and arsenic trioxide suppressed cell proliferative capacity and inhibited telomerase activity probably via transcriptional suppression of c-Myc and hTERT.

References

1. Damm, K., et al. EMBO J. 2001, 20, 6958?6968.
2. Bashash D., et al. Leuk Lymphoma. 2013 Mar;54[4]:561-8.
3. Bashash D., et al. Anticancer Agents Med Chem. 2013 Sep;13(7):1115-25.

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BIBR 1532

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