Costunolide

Catalog #

27745-2

$165 *

Size: 10 mg

Qty

Bulk/Custom

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Description

Costunolide is a sesquiterpene lactone with anti-oxidant properties that is found in lettuce and other plants. It is widely used in many herbal medicines. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.

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Synonyms

(+)-Costunolide; Costunolid; Costus lactone; NSC 106404

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Product Data Gallery

Product Info

Storage and Usage

Citations

Formula

C₁₅H₂₀O₂

232.3 Da

Solubility

Soluble in DMSO

Biological Activity

Costunolide is an inhibitor of human telomerase activity (IC50 = 65 µM in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines.Selectively blocks endothelial cell proliferation induced by VEGF and inhibits the VEGFR KDR/Flk-1 signaling pathway. Inhibits expression of iNOS and IL-1β and disrupts NF-?B activation. Exposure of T24 cells to costunolide was associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP.

CAS Registry #

553-21-9

References

1. Park et al (1996). J.Nat.Prod. 59 1128.
2. Jeong et al (2002). Cancer Lett. 187 129.
3. Choi et al (2005). Cancer Lett. 227 153.

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Costunolide

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