Human beta Defensin-2 Recombinant

Catalog #

90107-A

$130 *

Size: 5 µg

Qty

Bulk/Custom

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Description

Recombinant beta Defensin-2 is a disulfide-linked monomer protein consisting of 42 amino acid residues, and migrates as an approximately 4 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human beta Defensin-2 mature chain was expressed in E. coli.

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Synonyms

BD2, beta defensin 2, DEFB4

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered 100 mM NaCl, 20 mM phosphate buffer, pH 7.4.

4 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–64

Biological Activity

The ED₅₀ was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/ml.

Genbank #

O15263

UniProt #

O15263

Background

Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that defensins function in the eradication of pathogens from the host system by inserting themselves into the bacterial membrane under the influence of membrane potential, forming channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly effective in killing Gram negative bacteria. Its expression is also upregulated by the cytokine tumor necrosis factor-alpha.

References

1. J. Biol. Chem., Apr 2009, 284: 10034 - 10045.
2. J. Immunol., Feb 2009, 182: 1609 - 1616.
3. Endocrinology, Oct 2008, 149: 5189 - 5198.

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Human beta Defensin-2 Recombinant

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