Human beta Defensin-1 Recombinant

Catalog #

90106-A

$130 *

Size: 5 µg

Qty

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Description

Recombinant beta Defensin-1 is a disulfide-linked monomer protein consisting of 47 amino acid residues, and migrates as an approximately 5 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human beta Defensin-1 mature chain was expressed in E. coli.

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Synonyms

BD1, beta defensin 1, DEFB1

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered 100 mM NaCl, 20 mM phosphate buffer, pH 7.4.

5 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

33–68

Biological Activity

The ED₅₀ was determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 µg/ml.

Genbank #

P60022

UniProt #

P60022

Background

Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that defensins function in the eradication of pathogens from the host system by inserting themselves into the bacterial membrane under the influence of membrane potential, forming channels which lead to leakage of cytoplasmic molecules and cell death. Human beta-defensin-1, which has 36 amino acids, was originally isolated from hemofiltrates of patients with advanced renal failure. The BD-1 gene is expressed mainly in the urogenital tract and, to a lesser degree, in trachea and lung. BD-1 is believed to function in the antimicrobial defense of the urogenital and respiratory tracts.

References

1. J. Biol. Chem., Jan 2007, 282: 1819 - 1829.
2. Cancer Res., Sep 2006, 66: 8542 - 8549.
3. Infect. Immun., Apr 2006, 74: 2338 - 2352.

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Human beta Defensin-1 Recombinant

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