Human TARC(CCL17) Recombinant
Catalog #
90241-B
$205
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Description
Recombinant TARC (CCL17) is a disulfide-linked monomeric protein consisting of 71 amino acid residues and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human TARC (CCL17) mature chain was expressed in E. coli.
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Synonyms
TARC, CCL17, Thymus and activation-regulated chemokine, ABCD-2
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered 20 mM phosphate buffer, 100 mM NaCl solution, pH 7.5.
MW
8 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity
Determined by its ability to chemoattract human T cells using a concentration range of 2.0-40.0 ng/ml.
UniProt #
Q92583
Background
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T-cells that express a class of high affinity receptors binding TARC. The chemokine TARC is a ligand for the chemokine receptor CCR4 expressed on T helper (Th)2- type CD4 T cells.
References
1. Saeki H, Tamaki K. J Dermatol Sci. 2006 Aug,43(2):75-84.
2. Biragyn A, et al. J Immunother. 2013 May,36(4):258-67.
2. Biragyn A, et al. J Immunother. 2013 May,36(4):258-67.
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