Human Resistin Recombinant
Catalog #
90233-B
$205
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Description
Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Resistin mature chain was expressed in E. coli.
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Synonyms
Resistin, FIZZ3, Adipose Tissue-Specific Secretory Factor, ADSF, XCP1
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered PBS solution with 1 mM DTT.
MW
10 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
17–108
Biological Activity
Determined by its ability to stimulate lipolysis in cultured human adipocytes.
Genbank #
Q9HD89
UniProt #
Q9HD89
Background
Resistin was identified by screening for genes that are induced during the differentiation of adipocytes but down-regulated in mature adipocytes. Resistin gene expression is induced during the differentiation of adipocytes. Resistin circulates in mouse serum, and its level is increased markedly in obesity. Adipocytes secrete resistin as a unique signaling molecule that may be the hormone potentially linking obesity to type II diabetes, which is characterized by target-tissue resistance to insulin. TNF-alpha is a negative regulator of Resistin gene expression and inhibits Resistin mRNA expression and protein secretion by 70-90% in 3T3-L1 adipocytes.
References
1. Al-Suhaimi EA, Shehzad A. Eur J Med Res. 2013 May 1,18:12.
2. Lee SE, Kim HS. J Smooth Muscle Res. 2012,48(1):27-35.
3. Tiaka EK, et al. Cytokine Growth Factor Rev. 2011 Apr,22(2):109-19.
2. Lee SE, Kim HS. J Smooth Muscle Res. 2012,48(1):27-35.
3. Tiaka EK, et al. Cytokine Growth Factor Rev. 2011 Apr,22(2):109-19.
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