Human MIP4(CCL18) Recombinant

Catalog #

90221-B

$205 *

Size: 25 µg

Qty

Bulk/Custom

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Description

Recombinant CCL18 is a disulfide-linked homodimeric protein consisting of 70 amino acid residues and migrates as an approximately 16 kDa protein under non-reducing conditions and 8 kDa under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-4 mature chain was expressed in E. coli.

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Synonyms

CCL18, MIP4, MIP-4, PARC, Pulmonary And Activation-Regulated Chemokine, Macrophage Inflammatory Protein 4, DCCK1, AMAC1

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥98% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 100 mM NaCl, pH 7.5.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

21–89

Biological Activity

Determined by its ability to chemoattract human T cells using a concentration range of 2.0-40.0 ng/ml.

Genbank #

P55774

UniProt #

P55774

Background

CCL18, also designated dendritic cell (DC)3-derived CC chemokine 1, pulmonary and activation-regulated chemokine, alternative macrophage activation-associated CC chemokine 1, and MIP-4, is a human chemokine structurally related to CCL3. CCL18 was shown to be expressed in germinal centers of tonsils by dendritic cells and to attract mainly naive T cells, CD38^—, mantle zone B lymphocytes and DC. The production of CCL18 by APC is enhanced by Th2 cytokines like IL-4 and IL-13 and suppressed by IFN-gamma.

References

1. Chest, Feb 2009, 135: 295 - 302.br>2. J. Immunol., Jul 2008, 181: 1215 - 1223.
3. Ann Rheum Dis, Oct 2007, 66: 1334 - 1338.

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Human MIP4(CCL18) Recombinant

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