Human MIP-3A(CCL20) Recombinant
Catalog #
90220-B
$205
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Description
Recombinant MIP-3(CCL-23) is a disulfide-linked monomeric protein consisting of 100 amino acid residues and migrates as an approximately 11 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIP-3 mature chain was expressed in E. coli.
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Synonyms
CCL20, MIP3a, MIP-3alpha, SCYA20, LARC, Exodus1, Exodus-1
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered 20 mM Phosphate buffer, 100 mM NaCl, pH 7.5.
MW
11 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
27–96
Biological Activity
Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/ml.
Genbank #
P78556
UniProt #
P78556
Background
Macrophage inflammatory protein (MIP)-3/CCL20, also known as liver and activation-regulated chemokine (LARC) or Exodus, is a member of the CC chemokine subfamily initially noted to be expressed in human liver, lung, appendix, and tonsillar crypts. MIP-3 is selectively chemotactic for CD34+ bone marrow cell-derived immature DCs and CD45RO+ memory T cells that express the cognate receptor CCR6. MIP-3 produced at sites of inflammation may chemoattract CCR6-expressing immature DCs to the subepithelial region of mucosal surfaces.
References
1. J Rheumatol, Nov 2009, 36: 2397 - 2402.
2. Arterioscler Thromb Vasc Biol, Oct 2009, 29: 1608 - 1614.
3. Rheumatology, Jul 2009, 48: 741 - 747.
2. Arterioscler Thromb Vasc Biol, Oct 2009, 29: 1608 - 1614.
3. Rheumatology, Jul 2009, 48: 741 - 747.
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