Human MIG Recombinant

Catalog #

90216-B

$205 *

Size: 20 µg

Qty

Bulk/Custom

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Description

Recombinant MIG (CXCL9) is a disulfide-linked monomeric protein consisting of 104 amino acid residues, migrates as an approximately 11 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human MIG mature chain was expressed in E. coli.

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Synonyms

CXCL9, monokine induced by IFN-gamma, MIG, Humig, SCYB9, C-X-C Motif Chemokine 9

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered 1.0 mg/ml solution in 25 mM NaCl, 10 mM phosphate buffer, pH 7.0.

11 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

23–125

Biological Activity

Determined by its ability to chemoattract human peripheral blood T lymphocytes using a concentration range of 10.0-80.0 ng/ml.

Genbank #

Q07325

UniProt #

Q07325

Background

MIG (CXCL9) protein belongs to the family of chemotactic cytokines known as chemokines. The synthesis of MIG (CXCL9) is specifically induced in macrophages and in other cells by IFN-gamma. Human neutrophils produce MIG in response to IFN-gamma in combination with either TNF-alpha or bacterial lipopolysaccharides and this response is blocked by IL-10 and IL-4. MIG is a chemoattractant for stimulated but not resting T-cells, however it is not active on neutrophils or monocytes. MIG is thought to be involved in T cell trafficking.

References

1. Am. J. Pathol., Jun 2009, 174: 2172 - 2181.
2. J. Clin. Endocrinol. Metab., May 2009, 94: 1803 - 1809.
3. Invest. Ophthalmol. Vis. Sci., Apr 2009, 50: 1977.

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Human MIG Recombinant

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