Human GRO-alpha (CXCL1) Recombinant

Catalog #

90149-B

$205 *

Size: 25 µg

Qty

Bulk/Custom

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Description

Recombinant GRO-a is a disulfide-linked homodimeric protein consisting of 74 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human GRO-alpha mature chain was expressed in E. coli.

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Synonyms

CXCL1, GRO-alpha, MGSA-a, NAP-3, Melanoma Growth Stimulating Activity Alpha

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered concentrated (1 mg/ml) solution in 40 mM NaCl, 10 mM phosphate buffer, pH 7.0.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

35–107

Biological Activity

Determined by the ability to chemoattract human neutrophils using a concentration range of 10.0-50.0 ng/ml.

Genbank #

P09341

UniProt #

P09341

Background

Growth regulated oncogene-alpha belongs to the family of chemotyctic cytokines called chemokines. It is identical with MGSA (melanoma growth stimulatory activity)and the new designation is CXCL1. This factor is known mainly because of its chemotactic activity. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively. Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils. All three GROs can bind with high affinity to the IL-8 receptor type B.

References

1. Arterioscler Thromb Vasc Biol, May 2008, 28: 1005 - 1011.
2. Clin. Cancer Res., Oct 2006, 12: 5951 - 5959.
3. Am J Physiol Lung Cell Mol Physiol, Jul 2006, 291: L66 - L74.

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Human GRO-alpha (CXCL1) Recombinant

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