Human Follicle Stimulating Hormone Recombinant
Catalog #
90138-B
$205
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Description
Recombinant human Follicle Stimulating Hormone, or FSH, is a heterodimeric protein consisting of 92 amino acids alpha chain and 111 amino acids beta chain. FSH migrates as an approximately 27 kDa glycoprotein. Optimized DNA sequence encoding human FSH mature chain was expressed in CHO.
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Synonyms
FSH, Follicle stimulating hormone, Follitropin
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
CHO
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered solution.
MW
27 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity
Activity was determined to be 1.36 x 104 IU/mg protein
UniProt #
P01225
Background
Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. FSH and LH act synergistically in reproduction. In women, in the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows it releases inhibin, which shuts off the FSH production. In men, FSH enhances the production of androgen- binding protein by the Sertoli cells of the testes and is critical for spermatogenesis. In both males and females, FSH stimulates the maturation of germ cells. In females, FSH initiates follicular growth, specifically affecting granulosa cells. With the concomitant rise in inhibin B, FSH levels then decline in the late follicular phase. This seems to be critical in selecting only the most advanced follicle to proceed to ovulation. At the end of the luteal phase, there is a slight rise in FSH that seems to be of importance to start the next ovulatory cycle. Like its partner LH, FSH release at the pituitary gland is controlled by pulses of gonadotropin- releasing hormone(GnRH). Those pulses, in turn, are subject to the estrogen feed-back from the gonads.
References
1. J. Endocrinol., Oct 2009, 203: 167 - 174.
2. Endocr. Relat. Cancer, Sep 2009, 16: 1005 - 1016.
2. Endocr. Relat. Cancer, Sep 2009, 16: 1005 - 1016.
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