Human Eotaxin-3(CCL26) Recombinant

Catalog #

90129-B

$205 *

Size: 20 µg

Qty

Bulk/Custom

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Description

Recombinant Eotaxin-3 is a disulfide-linked homodimeric protein consisting of 72 amino acid residues, and migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Eotaxin-3 mature chain was expressed in E. coli.

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Synonyms

CCL26, Eotaxin-6, SCYA26, Thymic Stroma Chemokine-1, TSC-1, IMAC, MIP-4alpha, MIP4a

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered PBS, pH 7.5 with 10% glycerol.

9 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–94

Biological Activity

Biological activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/ml.

Genbank #

Q9Y258

UniProt #

Q9Y258

Background

Eotaxin belongs to the platelet factor-4 family of chemokines. The factor is being referred to also as Eotaxin-2 and has been renamed CCL24. Both eotaxin-2/CCL24 and eotaxin-3/CCL26 are CC chemokines and functional ligands for CC chemokine receptor 3 (CCR3), which is preferentially expressed on eosinophils. Only 34% of the amino acids in eotaxin-2/CCL24 and eotaxin-3/CCL26 are identical, but these two chemokines have a common characteristic feature in terms of chemotaxis for eosinophils via the CCR3.

References

1. J Rheumatol, Aug 2009, 36: 1590 - 1595.
2. Rheumatology, Jun 2008, 47: 804 - 808.
3. Eur. Respir. J., Nov 2005, 26: 795 - 803.

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Human Eotaxin-3(CCL26) Recombinant

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