Human Eotaxin-2 (CCL24) Recombinant
Catalog #
90128-B
$205
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Description
Recombinant Eotaxin-2 is a disulfide-linked homodimeric protein consisting of 79 amino acid residues, and migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Eotaxin-2 mature chain was expressed in E. coli.
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Synonyms
CCL24, MPIF2, Eotaxin-2, SCYA24
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥97% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered concentrated (1.0 mg/ml) solution in 100 mM NaCl, 10 mM phosphate buffer, pH 7.0.
MW
9 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
27–104
Biological Activity
Biological activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/ml.
Genbank #
O00175
UniProt #
O00175
Background
Eotaxin belongs to the platelet factor-4 family of chemokines. The factor is being referred to also as Eotaxin-2 and has been renamed CCL24. Both eotaxin-2/CCL24 and eotaxin-3/CCL26 are CC chemokines and functional ligands for CC chemokine receptor 3 (CCR3), which is preferentially expressed on eosinophils. Only 34% of the amino acids in eotaxin-2/CCL24 and eotaxin-3/CCL26 are identical, but these two chemokines have a common characteristic feature in terms of chemotaxis for eosinophils via the CCR3.
References
1. Clin. Cancer Res., Oct 2007, 13: 5719 - 5728.
2. J. Biol. Chem., Apr 2005, 280: 13952 - 13961.
3. J. Immunol., Sep 2002, 169: 2712 - 2718.
2. J. Biol. Chem., Apr 2005, 280: 13952 - 13961.
3. J. Immunol., Sep 2002, 169: 2712 - 2718.
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