Human Eotaxin-1 (CCL11 ) Recombinant

Catalog #

90127-B

$205 *

Size: 20 µg

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Description

Recombinant Eotaxin-1 is a disulfide-linked homodimeric protein consisting of 75 amino acid residues, and migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Eotaxin-1 mature chain was expressed in E. coli.

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Synonyms

CCL11, SCYA11, Eotaxin-1

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥97% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered solution (1 mg/ml) in PBS, pH 7.4.

9 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–97

Biological Activity

Biological activity was determined by the ability to induce chemotaxis of purified eosinophils at concentrations ranging between 50-100 ng/ml.

Genbank #

P51671

UniProt #

P51671

Background

Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils .

References

1. Clin. Cancer Res., Apr 2009, 15: 2647 - 2656.
2. Int. Immunol., Feb 2009, 21: 187 - 201.
3. J. Immunol., Nov 2008, 181: 7390 - 7399.

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Human Eotaxin-1 (CCL11 ) Recombinant

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