Mouse Eotaxin Recombinant

Catalog #

90126-B

$205 *

Size: 20 µg

Qty

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Description

Recombinant mouse Eotaxin is a disulfide-linked homodimeric protein consisting 75 amino acid residues, and migrates as an approximately 8 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Mouse Eotaxin mature chain was expressed in E. coli.

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Synonyms

CCL11, SCYA11, Eotaxin-1

Product Info

Storage and Usage

Citations

Species

Mouse

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered PBS solution, pH 7.4.

8 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

24–97

Biological Activity

Biological activity was determined by the ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-20.0 ng/ml.

Genbank #

P48298

UniProt #

P48298

Background

Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils .

References

1. Clin. Cancer Res., Apr 2009, 15: 2647 - 2656.
2. Int. Immunol., Feb 2009, 21: 187 - 201.
3. J. Immunol., Nov 2008, 181: 7390 - 7399.

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Mouse Eotaxin Recombinant

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