Human Endocrine Gland Vascular Endothelial Growth Factor Recombinant
Catalog #
90122-B
$205
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Description
Recombinant EG-VEGF is a disulfide-linked monomer protein consisting of 87 amino acid residues, and migrates as an approximately 10 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human EG-VEGF mature chain was expressed in E. coli.
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Synonyms
Endocrine-Gland-Derived Vascular Endothelial Growth Factor, EG-VEGF, Prokineticin 1, Mambakine,
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered PBS solution.
MW
10 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
20–105
Genbank #
P58294
UniProt #
P58294
Background
This factor is identical with prokineticin-1 and is a member of the AVIT protein family. Expression of human EG-VEGF messenger RNA is restricted to the steroidogenic glands, ovary, testis, adrenal and placenta and is often complementary to the expression of VEGF. EG-VEGF has been identified as a mitogen specific for the endothelium of steroidogenic glands. EG-VEGF resembles VEGF in that it causes extensive angiogenesis and cyst formation when delivered in the ovary. EG-VEGF differs from VEGF in that it does not promote angiogenesis in the cornea or skeletal muscle. Two receptors (the G-protein-coupled receptor ZAQ and the G-protein-coupled receptor I5E) have been characterized, these receptors are expressed in gastrointestinal organs, endocrine glands and other tissues.
References
1. Endocrinology, Sep 2006, 147: 4245 - 4251.
2. J. Leukoc. Biol., Aug 2005, 78: 426 - 434.
2. J. Leukoc. Biol., Aug 2005, 78: 426 - 434.
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