CD38 (Mouse) Fluorogenic Assay Kit (Cyclase Activity)
The CD38 (Mouse) Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 (mouse) for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercetin for use as an inhibitor control.
Assay Principle
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Adjustable micropipettor and sterile tips
Fluorescent microplate reader
Rotating or rocker platform
| Catalog # | Name | Amount | Storage |
| 79070 | CD38, His-Tag (Mouse), HiP™ | 2 x 1 µg | -80°C |
| 3x CD38 cyclase assay buffer | 4 ml | -20°C | |
| CD38 substrate NGD+ | 50 µl | -20°C | |
| Quercetin (50 mM in DMSO) | 100 µl | -20°C | |
| 79685 | Black 96-well plate | 1 | Room Temp. |
*The initial concentration of CD38 is lot-specific and will be indicated on the tube containing the protein.
CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic b cells, where it regulates insulin secretion. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia, and anti-CD38 antibodies are in clinical trials as therapeutics for multiple myeloma.
Wei, W., et al., World J. Biol. Chem. 2014, 5(1):58-67.
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