CD38 (Dog) Inhibitor Screening Assay Kit (Hydrolase Activity)
The Dog CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of canine CD38 for screening and profiling applications.
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Adjustable micropipettor and sterile tips
Fluorescent microplate reader
Rotating or rocker platform
| Catalog | Component | Amount | Storage | |
| 100955 | CD38 (Dog) | 1 µg | -80°C | Avoid multiple freeze/ thaw cycles! |
| 4x CD38 hydrolase buffer | 4 ml | -20°C | ||
| CD38 substrate (ε-NAD) |
50 µl | -20°C | ||
| Apigenin (50 mM in DMSO) | 10 µl | -20°C | ||
| 79685 | Black 96-well plate | 1 | Room Temp |
|
CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein that functions as an ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. The major enzymatic activity of CD38 is the hydrolysis of NAD. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic ß cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Koguma, T., et al. Biochim. Biophys. Acta -- Mol. Cell. Res. 1994. 1223(1): 160-162
Malavasi, F., et al. Physiol. Rev. 2008. 88(3): 841-886
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