Anti-PSMA-Anti-CD3 IgG format Bispecific Antibody

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Catalog #

101242

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Description

Anti-PSMA-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of PSMA-CHO cells (BPS Bioscience #79641-H).

PSMA (Prostate-Specific Membrane antigen), also known as FOLH1 (folate hydrolase 1) and NAALADase I (N-acetyl-L-aspartyl-L-glutamate peptidase I) is a transmembrane protein highly expressed in the intestine, the prostate, and the nervous system. The protein is a glutamate carboxypeptidase involved in folate metabolism and may be involved in pathological conditions such as hyperhomocysteinemia (intestine) and glutamate toxicity (nervous system).

PSMA is overexpressed in prostate cancer cells and is the target of an increasing number of diagnostic and therapeutic approaches used for the treatment of prostate cancer.

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Synonyms

PSMA, Prostate-Specific Membrane antigen, FOLH, FOLH1, folate hydrolase 1, NAALAD1, NAALADase I, N-acetyl-L-aspartyl-L-glutamate peptidase I, PSM, FGCP, Glutamate carboxypeptidase, GCP2, membrane glutamate carboxypeptidase, mGCP, GCPII

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining of the bispecific antibody

Activation of luciferase in NFAT-Jurkat Reporter cells by AntiPSMA-Anti-CD3 IgG in the presence of PSMA-CHO cells

Product Info

Storage and Usage

Citations

Species

Human

Construct

Anti-PSMA-Heavy and Light Chains, Anti CD3-Heavy and Light Chains

Isotype

IgG1

Host Species/Expression System

Co-expressed in HEK293

Purity

≥90%

Purification

Protein A affinity purification of the IgG-tag protein from HEK293 cells.

Format

Aqueous buffer solution

Formulation

8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol

~150 kDa (Heavy Chain: 50 kDa; Light Chain: 24 kDa)

UniProt #

Q04609

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Datasheets/Protocols

101242 Lot 211109

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Anti-PSMA-Anti-CD3 IgG format Bispecific Antibody

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